Procyclidine Abuse

Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4.

The goals of the present study were: (1) to investigate the binding properties of (R)- and (S)-procyclidine and two achiral derivatives of muscarinic M1, M2 and M4 receptor subtypes and (2) to identify the interactions which allow these receptors to discriminate between the two stereoisomers. (R)-Procyclidine showed a higher affinity for human neuroblastoma NB-OK 1 muscarinic M1 and rat striatu...

KEMADRIN Tablets Procyclidine Hydrochloride 5 mg Tablets Qualitative and Quantitative Composition

Alcohol Abuse and Oral Cancer

Background: Various medical, psychiatric and social problems affecting alcohol abuser tend to overshadow their oral health. From an epidemiologic viewpoint, chronic consumption of alcoholic beverages is associated with an increased risk for the upper gastrointestinal tract cancer, and tobacco and alcohol are regarded as the major risk factors for oral cancer. The objective of this presentation ...

Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study.

Prepulse inhibition (PPI) of the startle response refers to a reduction in response to a strong stimulus (pulse) if this is preceded shortly by a weak non-startling stimulus (prepulse). Consistent with theories of deficiencies in early stages of information processing, PPI is found to be reduced in patients with schizophrenia. Atypical antipsychotics are found to be more effective than typical ...

Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors.

We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of oxyphencyclimine were studi...